Ancient Natural Painkillers

Datura

Although it was derived from a poisonous plant, Datura (thorn apple or jimsonweed) was a popular ancient pain reliever and sleep inducer. It’s mentioned in medical texts by Dioscorides (AD 40–90), Theophrastus (370–285 BC), Celsus (fl. AD 37), and Pliny the Elder (AD 23–79). The drug had several serious side effects. A drachma (3.411 grams) taken with wine could cause hallucinations, while two drachmas could cause madness for as long as three days. Greater quantities could cause permanent insanity or even death. Although Datura was effective in relieving patients’ pain during ancient surgical procedures, it also resulted in their deaths when it was improperly administered. For this reason, another popular name for Datura is “Devil’s apple.”