Migraines impact women’s brains in a different way All in all, women are more likely to suffer from migraines than men. The cause of migraines is pretty much the same – brain tissue swells and the swelling presses against nerves. The part of the brain impacted by migraine is different for women – amygdala that is responsible for processing emotions suffers the most. Parts of the brain that deal with pain also suffer more in women’s brains.