Movies that permanently damaged actors' bodies

Christian Bale in The Machinist (2004)
 Christian Bale wins the prize for the crazy extremes he's put his body through for his craft. He has gained weight (American Hustle), bulked up (Dark Knight series)—but it was his turn in the 2004 indie film The Machinist that became his most infamous transformation. As a patient suffering from insomnia, Bale lost 65 pounds by basically eating a single can of tuna fish or an apple a day, along with drinking black coffee and water.