Movies that permanently damaged actors' bodies

Antonia Campbell-Hughes in 3096 Days (2013)
3096 Days is an adaptation of the Natascha Kampusch memoir that details her life as a kidnapping victim who was trapped in her abductor's basement from ages 10-18. Her story is full of violence and abuse, as her captor systematically raped and starved her to break her will. When Antonia Campbell-Hughes got the part, she knew she was going to get into it all the way. "It's not a biopic or a case study," she explained. "But playing someone real, you feel you have to give a bit more. There was an understanding from the beginning that I would suffer as much as she did."