Movies that permanently damaged actors' bodies

Mila Kunis in Black Swan (2010)
This intense look into the world of ballet was, unsurprisingly, pretty hard on the bodies of its stars. Mila Kunis, who plays the understudy that Natalie Portman's character becomes obsessed with, lost 20 pounds to look like a ballerina. That might not sound too drastic, but it sent the 5'4" Kunis down to 95 pounds.