Movies that permanently damaged actors' bodies

Robert De Niro in Cape Fear (1991)
Robert De Niro is no stranger to putting his body through hell for a role. He famously gained 60 pounds to play Jake LaMotta in Raging Bull, and for Cape Fear, his transformation was more specifically extreme. To play a frightening criminal out for revenge, De Niro trained for six months to get his body fat down to a single digit. When he filmed the shirtless scenes, he cut weight like a fighter, refusing to drink any water during the shoot. He would only swish seltzer through his mouth and spit it out when he was dying for a drink.