Blue Fingertips Fingertips that change in color from white to blue to red can signal Raynaud's syndrome. "This condition causes coldness of the fingers and toes and can be accompanied by pain, numbness and tingling," Bank says. Experts believe Raynaud's occurs due to a spasm of blood vessels and decreased circulation, but the cause remains unknown. The best treatment: wearing gloves, taking prescribed medication, and avoiding emotional stress, smoking, and exposure to cold temperatures.