Loneliness Sounds counterintuitive, but you can catch feeling isolated, according to a recent study. "Loneliness makes people more negative, irritable and defensive," which can protect you if you're in an unsafe setting, says John T. Cacioppo, PhD, professor and director of the Center for Cognitive and Social Neuroscience at the University of Chicago in Illinois. Lonely folks are more likely to treat others badly; those people then do the same to others, and the cycle continues. Be aware of these effects, and when you're with a trusted friend, rein in behavior that might alienate people.