Gender refers to social aspects of being a woman or a man such as social stress, opportunity and social expectations. Sex, on the other hand, refers to biology. Biology can contribute to this difference in life expectancy. Women have biological advantages that let them live longer. For instance, estrogen benefits women because it lowers low-density lipoprotein cholesterol (or LDL, what you may know as “bad” cholesterol) and increases high-density lipoprotein cholesterol (or HDL, the “good” cholesterol), which reduces cardiovascular risk. Testosterone, on the other hand, increases blood levels of the bad cholesterol and decreases levels of good cholesterol. This puts men at greater risk of hypertension, heart disease and stroke.