Saffron Rich orange-red hued saffron, which is the stigma of a variety of crocus flower, adds lots of flavor to foods. It also has a “mood-improving effect” that could aid in weight loss and help you relax. In a study on mice, a water-based extract of saffron reduced anxiety and increased total sleep time.Saffron is largely cultivated and harvested by hand. Due to the amount of labor involved in harvesting, saffron is considered one of the world's most expensive spices. The stigmas are also used to make medicine. Saffron is used for asthma, cough, whooping cough (pertussis), and to loosen phlegm (as an expectorant).