More skin cancers are diagnosed in the U.S. each year than all other cancers combined, according to the American Cancer Society. Skin cancers develop in the cells of the skin when unrepaired DNA damage generates a genetic mutation that leads to the cells rapidly multiplying, forming malignant tumor. Melanin, which causes skin darkening, is protective against skin cancer. People with fair skin, blonde or red hair, blue or green eyes, and freckles usually have less natural melanin, putting them at higher risk.