Natural anti-inflammatory agents for pain relief

Capsaicin: 
The active component of chili peppers, capsaicin is often used topically to nerve, muscle, and joint pain. It works by interfering with substance P, a chemical that helps transmit pain signals to the brain. It is available as a topical cream or gels in several different potencies (most often, 0.025% to 0.075%) and is usually applied three to four times daily. It can cause some stinging and burning initially, but it typically subsides with use.