After establishing a theater and film career in Iran, Aghdashloo moved to England during the Iranian Revolution in 1979, and she subsequently became a citizen of the United States. After several years playing supporting roles in television and film, her performance in
House of Sand and Fog (2003) brought her several film critics' awards and a nomination for an Academy Award for Best Supporting Actress. She has continued to play supporting and character roles in film and television, and she won an Emmy Award for her work in the television drama
House of Saddam (2008).