Once food enters your mouth, it can take between two to six hours to hit your small intestine in a process known as gastric emptying. From there, the food will be digested for between two to six hours before going to your large intestine. This is where the food spends the longest amount of time, as it can take anywhere from 10 to 59 hours to pass, explains nutritionist Mackenzie Burgess, RDN.
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