Trust your gut-- if someone makes you upset and uncomfortable, make some space. When you walk into the store to buy a new box of Cheerios, you know immediately what kind of mood the cashier is in. You can see it, even feel it, in your interaction. You can do this with your friends and coworkers, too! Even if you don't see the tell-tale signs, you know when something is off, and you know to avoid some people. Trust yourself -- there are plenty of happy people out there without trying out all the sourpusses.