Some individuals may experience both at different times, while others may have an irregular sleep schedule. 6. Feelings of guilt or worthlessness: People with depression often internalize their struggles and may feel an overwhelming sense of guilt or worthlessness. They may excessively blame themselves for not being able to feel better or for perceived failures. 7. Social withdrawal: Depressed individuals may withdraw from social interactions, distancing themselves from friends, family, and activities they once enjoyed. They may isolate themselves due to a lack of interest, low self-esteem, or a fear of being a burden on others.