The first major health threat from both smoking and prolonged sitting is endothelial dysfunction, which refers to damage to the inner lining of the blood vessels. Smoking introduces massive amounts of free radicals that cause oxidative stress, directly injuring the endothelium and impairing its ability to produce nitric oxide (NO), a critical molecule that signals the smooth muscles to relax and allows blood vessels to dilate. Similarly, long, uninterrupted periods of sitting reduce the sheer stress—the friction of blood flow—on artery walls, which is a necessary stimulus for NO production. Dark chocolate flavanols, such as epicatechin, are potent antioxidants that actively scavenge these free radicals, effectively reducing the oxidative stress caused by smoking and enhancing the bioavailability of nitric oxide, thus helping to restore the endothelium's ability to function and promote healthy vasodilation.
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