5. One-Sided Vision Loss with Systemic Symptoms Sudden, painless vision loss in a single eye can be even more ominous when accompanied by systemic symptoms like headaches, jaw pain, scalp tenderness, or a general feeling of illness. These signs may indicate optic nerve inflammation or a condition called Giant Cell Arteritis (GCA). This is a serious inflammatory disease of the blood vessels that requires immediate treatment with high-dose corticosteroids; without prompt medical care, it can lead to permanent bilateral blindness or even a cerebral stroke.
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