Tenderness of swelling in your lymph nodes, the small bean-shaped glands found in your neck, armpits, and other places, often signal that something's going on in your body. Usually, it means your immune system is fighting a sore throat or cold, but certain cancers can also trigger the changes. Have your doctor check any swelling or tenderness that doesn't get better in 2 to 4 weeks, Meyers says.
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