Exercise has a substantial effect on the brain and body, both in the short- and long-term.There is some evidence that muscle activation during exercise allows more tryptophan, which the body converts to serotonin, to cross the blood-brain barrier.Most of the evidence for exercise increasing serotonin comes from animal studies, though there are some examples in humans.Increasing serotonin levels is one of several ways in which exercise might treat depression.
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