Homa was married in 1963 to her classmate Manoochehr Keyhani. After graduation she practiced in a village called Bahmanieh in northern Iran. In 1967 she went to the United States after obtaining a residency in pediatrics. Dr. Darabi lived in the U.S. for nine years and even got U.S. citizenship.
In 1976 she returned to Iran to serve her country as one of the most prominent child psychiatrists.