Spots on the Skin These usually appear on the arms, legs, or back. They may be darker or lighter than normal skin, or slightly red. They don’t burn or hurt, but they may become raised, and nodules may form. Painless Swelling This occurs on the face and earlobes. Eye Issues Light sensitivity can be an early symptom. And if the disease has invaded facial nerves, the blinking reflex can be lost, which can lead to dry eyes, ulcers, and even blindness.